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Axis Clinical Software Inc
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QUALISYS LIMITED
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OpenSim Ltd
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SourceForge net
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Cell Signaling Technology Inc
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MOCAP Inc
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2026-04
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Macquarie Bank
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2026-04
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QUALISYS LIMITED
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ComScore Inc
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Image Search Results
Journal: eLife
Article Title: A non-genetic, cell cycle-dependent mechanism of platinum resistance in lung adenocarcinoma
doi: 10.7554/eLife.65234
Figure Lengend Snippet: ( A ) Representative images and quantification of A549, NCI-H1573, and CI-H1299 cells 3 days after cisplatin exposure stained for beta-galactosidase. Scale bar = 100 µm. Shown are the mean ± SD of three biological repeats. Statistical significance was determined by unpaired two-tailed Student’s t-test (****p<0.0001, ***p<0.001, **p<0.01). ( B ) FACS analysis of beta-galactosidase activity levels (C 12 FDG) versus ‘cell size’ (forward scatter [FSC]) and ( C ) p21, p16 and at 3 days after cisplatin exposure. Shown are the mean ± SD of three biological repeats. Statistical significance was determined by unpaired two-tailed Student’s t-test (****p<0.0001, ***p<0.001, *p<0.05). ( D ) Three biological repeat experiments of LeGO RGB colour-guided clonal cell tracking system were used to track clonal dynamics after cisplatin pulse treatment in each cell line. Cells were treated as per , with clonal identification and quantification measured at 3 and 21 days post-cisplatin exposure using Image J/Fiji (42 days post-cisplatin exposure for NCI-H1573). For summary data, only colours that represented >0.1% of total population were scored.
Article Snippet: Antibody ,
Techniques: Staining, Two Tailed Test, Activity Assay, Cell Tracking Assay
Journal: eLife
Article Title: A non-genetic, cell cycle-dependent mechanism of platinum resistance in lung adenocarcinoma
doi: 10.7554/eLife.65234
Figure Lengend Snippet: Briefly, cells exposed in G1 undergo S/G2 phase arrest, marked by high levels of P70S6K, p53, and p21, which results in a stable and permanent cell cycle exit from G2 phase. Cells in late S phase likely receive platinum adducts in areas of already duplicated DNA, with error-prone non-homologous end joining (NHEJ) favoured over homologous recombination (HR). Combining this with an increase in cells undergoing aberrant division results in daughter cells displaying higher rates of damage during replication, further resulting in S/G2 arrest and senescence. In contrast, cells in late G1/early S phase have the opportunity to detect and repair damage by HR during the first cycle, thereby increasing chances that daughter cells will successfully complete and repair damage, allowing continued proliferation.
Article Snippet: Antibody ,
Techniques: Non-Homologous End Joining, Homologous Recombination
Journal: eLife
Article Title: A non-genetic, cell cycle-dependent mechanism of platinum resistance in lung adenocarcinoma
doi: 10.7554/eLife.65234
Figure Lengend Snippet:
Article Snippet: Antibody ,
Techniques: Transfection, Construct, Plasmid Preparation, Gene Expression, Membrane, Software, Imaging